Alzheimer's Disease: Modelization, Biomarkers, Preclinical Imaging,
Therapeutic Evaluations
UMR CEA CNRS 9199, MIRCen
18 Route du Panorama, 92265 Fontenay aux Roses, France
Resp. Marc Dhenain

Publications from PubMed list

Publications since 2007 (access to pdf)

2017

2016

2015

- Djelti F., Braudeau J., Hudry E., Dhenain M., Varin J, Bièche I., Marquer C., Chali F., Ayciriex S., Alves S., Langui D., Potier M.C., Duyckaerts C., Miles R., Aubourg P., Cartier N. Excess of brain cholesterol triggers neuronal death and paves the way for Alzheimer’s disease. Brain. 2015. 138, 2383-2398.

- Pifferi F., Dorieux O., Castellano C. A., Croteau E., Masson M., Guillermier M., Van Camp N., Guesnet P., Alessandri J. M., Cunnane S., Dhenain M., Aujard F.. Dietary omega3 polyunsaturated fatty acids enhance resting state brain glucose utilization and reduce anxiety in an adult non-human primate, the grey mouse lemur (Microcebus murinus). Journal of Lipid Research. 2015. 56 (8), 1511-1518.

- Dhenain M. Stratégie de recherche translationnelle sur la maladie d'Alzheimer : cibles, modèles animaux et biomarqueurs. Bulletin de l'Académie Nationale de Médecine. 2015. 199(6): 893-908.

- Dhenain M. Imagerie cérébrale : Outils, principes et utilisations de la clinique aux sciences cognitives comparatives. Bulletin de l'Académie Vétérinaire de France. 2015. 168(2): 164-171.

- Ben Haim L., Ceyzeriat K., Carrillo de Sauvage M.A., Aubry F., Auregan G., Guillermier M., Houitte D., Petit F., Faivre E., Vandesquille M., Dhenain M., Déglon N., Hantraye P., Brouillet E., Bonvento G., Escartin C.. The JAK/STAT3 pathway is a common mediator of astrocyte reactivity in neurodegenerative disease models. J Neuroscience. 2015. 35(6): 2817-2829.

- Roy M., Cardoso C., Dorieux O., Malgorn C., Epelbaum S., Kraska A., Brouillet E., Delatour B., Perret M., Aujard F., Dhenain M.. Age-associated evolution of plasmatic amyloid in mouse lemur primates: Relationship with neuronal accumulation of amyloid-ß precursor protein, Neurobiology of Aging. 2015. 36: 149-156.

2013

- Santin, M.D., Debeir, T., Bridal, S.L., Rooney, T., Dhenain, M. Fast in vivo imaging of amyloid plaques using µ-MRI Gd-staining combined with ultrasound-induced blood brain barrier opening. NeuroImage.2013. 79: 288-294.

- Joseph-Mathurin N., Dorieux O., Trouche S., Boutajangout A., Kraska A., Verdier J.M., Sigurdsson E.M., Mestre-Francés N., Dhenain M., Abeta immunization in old mouse lemur primates induces cerebral microhemorrhages and accelerates age-associated iron deposits in the choroid plexus. Neurobiology of Aging, 2013. 34(11): 2613-2622.

- Bertrand A., Pasquier A., Petiet A., Wiggins C., Kraska A., Joseph-Mathurin N., Aujard F., Mestre-Francés N., Dhenain M. Micro-MRI study of cerebral aging: Detection of hippocampal subfield reorganization, microhemorrhages, and amyloid plaques in mouse lemur primates. PlosOne 2013. 8(2), e56593. doi:56510.51371/journal.pone.0056593..

- Kraska A, Santin MD, Dorieux O, Joseph-Mathurin N, Bourrin E, Petit F, Jan C Chaigneau M, Hantraye P, Lestage P, Dhenain M. In Vivo cross-sectional characterization of cerebral alterations induced by intracerebroventricular administration of streptozotocin. Plos One. 25 Sept 2012. 10.1371/journal.pone.0046196.

- Poisnel G, Hérard AS, El Tannir El Tayara N, Bourrin E, Volk A, Kober F, Delatour B, Delzescaux T, Debeir T, Rooney T, Benavides J, Hantraye P, Dhenain M. Increased regional cerebral glucose uptake in an APP/PS1 model of Alzheimer's disease. Neurobiology of Aging. 2012. 33 (9). 1995-2005.

- Petiet A, Santin M., Bertrand A., Wiggins C. J., Petit F., Houitte D., Hantraye P., Benavides J., Debeir T., Rooney T., Dhenain M.. Gadolinium-staining reveals amyloid plaques in the brain of Alzheimer’s transgenic mice. Neurobiology of Aging. 2012. 33(8). 1534-1544.

- Picq J-L., Aujard F., Volk A., Dhenain M.. Age-related cerebral atrophy in mouse lemur primates: relationship with cognitive impairments. Neurobiology of Aging. 2012. 33(6). 1096-1109.

- Languille S., Blanc S., Blin O., Canale C, Dal-Pan A., Deveau G., Dhenain M., Dorieux O., Epelbaum J., Gomez D., Hardy I., Henry P. Y., Irving E, Marchal J.,  Mestre-Francès N., Perret M., Picq J. L., Pifferi F., Rahman A., Schenker E., Terrien J., Théry M., Verdier J. M., Aujard F. The grey mouse lemur: a non human primate model for ageing studies. Ageing Research Review. 2012 11(1). 150-162.

- Gobbo O.L., Petit F., Gurden H., Dhenain M.. In vivo detection of excitotoxicity by manganese-enhanced MRI: Comparison with physiological stimulation. Magnetic Resonance in Medicine. 2012. 68 (1). 234-240.

2011

- Lebenberg J., Hérard A-S., Dubois A., Dhenain M., Hantraye P., Delzescaux T. A combination of atlas-based and voxel-wise approaches to analyze metabolic changes in autoradiographic data from Alzheimer’s mice. NeuroImage. 2011. 57(4): 1447-57.

- Petiet A., Dhenain M. Improvement of microscopic MR imaging of amyloid plaques with targeting and non-targeting contrast agents. Current Medical Imaging Reviews. 2011, 7(1): 8-15.

- Kraska A., Dorieux O., Picq J-L, Petit F., Bourrin E., Chenu E., Volk A., Perret M., Hantraye P., Mestre-Frances M., Aujard F., Dhenain M. Age associated cerebral atrophy in mouse lemur Primates. Neurobiology of Aging. 2011. 32 (5) 894–906.

- Faure A., Verret L., Bozon B., El Tayara N., Ly M., Kober F., Dhenain M., Rampon C., Delatour B. Impaired neurogenesis, neuronal loss, and brain functional deficits in the APPxPS1-Ki mouse model of Alzheimer’s disease. Neurobiology of Aging. 2011. 32(3): 407-418.

2010

- Lebenberg J, Herard AS, Dubois A, Dhenain M, Hantraye P, Delzescaux T. Automated indexation of metabolic changes in Alzheimer's mice using a voxel-wise approach combined to an MRI-based 3D digital atlas. Conf Proc IEEE Eng Med Biol Soc. 2010. 2010: 5636-9.

- El Tannir El Tayara N., Delatour B., Volk A., Dhenain M.. Detection of vascular alterations by in vivo magnetic resonance angiography and histology in APP/PS1 mouse model of Alzheimer's disease. Magnetic Resonance Materials in Physics, Biology and Medicine. 2010, 23(1): 53-64.

- Lebenberg J., Herard A-S., Dubois A., Dauguet J., Frouin V., Dhenain M., Hantraye P., Delzescaux T.. Validation of MRI-based 3D digital atlas registration with histological and autoradiographic volumes: an anatomo-functional transgenic mouse brain imaging study. Neuroimage. 2010, 51(3): 1037-1046.

- Dubois A., Hérard A.S., Delatour B., Hantraye P., Bonvento G., Dhenain M., Delzescaux T. Detection by voxel-wise statistical analysis of significant changes in regional cerebral glucose uptake in an APP/PS1 transgenic mouse model of Alzheimer's disease. Neuroimage. 2010, 51(2): 586-598.

- Delatour B., Epelbaum S., Petiet A., Dhenain M. In vivo imaging biomarkers in mice models of Alzheimer’s disease: Are we lost in translation or breaking through? International Journal of Alzheimer's Disease. 2010, Article ID 604853, doi:10.4061/2010/604853 (http://www.sage-hindawi.com/journals/ijad/2010/604853.html ).

- Joseph Mathurin N., Dorieux O., Kraska A., Bertrand A., Santin M., El Tannir El Tayara N., Dhenain M.. Magnetic resonance imaging in primates. The example of the mouse lemur (Microcebus murinus): From detection of pathological aging to therapeutic evaluations. Revue de Primatologie [On line:  http://primatologie.revues.org/508], 2 | 2010.

2009

- Lebenberg J., Herard A.S., Dubois A., Dhenain M., Hantraye P., Frouin V., Delzescaux T.. Segmentation of anatomo-functional 3D-post mortem data using a MRI-based 3D digital atlas : transgenic mouse brain study. IEEE International Symposium on Biomedical Imaging - From Nano to Macro. 2009, 1-2: 1182-1185

2008

- Dhenain M.. Preclinical MRI and NMR biomarkers of Alzheimer's disease: Concepts and applications. Magnetic Resonance Insights. 2008:2 75–91.

- Pain F., Dhenain M., Gurden H., Routier A. L., Lefebvre F., Mastrippolito R., Lanièce P. A method based on Monte Carlo simulations and voxelized anatomical atlases to evaluate and correct uncertainties on radiotracer accumulation quantitation in beta microprobe studies in the rat brain. Physics in Medicine and Biology. 2008, 53: 1-20.

- Delatour B., Dhenain M.. Le diagnostic de la maladie d’Alzheimer : l’apport de la recherche préclinique. [Diagnosis of Alzheimer's disease : the contribution of preclinical research]. Bulletin de l'Académie Nationale de Médecine. 2008, 192(2): 345-361.

2007

- El Tannir El Tayara N., Volk A., Dhenain M. *, Delatour B*. Transversal relaxation time reflects brain amyloidosis in young APP/PS1 transgenic mice. Magnetic Resonance in Medicine. 2007, 58(1): 179-184.

- Escartin C., Pierre K., Brouillet E., Delzescaux T., Guillermier M., Dhenain M., Déglon N., Hantraye P., Pellerin L., Bonvento G. Activation of astrocytes by CNTF induces metabolic plasticity and increases resistance to metabolic insults. Journal of Neuroscience. 2007, 27(27): 7094-7104.

- Quintana C., Wu T. D., Delatour B., Dhenain M., Guerquin-Kern J-L., Croisy A.. Morphological and chemical studies of pathological human and mice brain at the sub cellular level: correlation between light, electron and nanoSIMS microscopies. Microscopy Research and Technique. 2007, 70(4): 281-295.

- Kappeler C, Dhenain M., Phan Dinh Tuy F., Saillour Y., Marty S., Fallet-Bianco C., Souville I., Souil E., Pinard J-M., Meyer G., Encha-Razavi F., Volk A., Beldjord C., Chelly J., Francis F. MRI and histological studies of corpus callosal and hippocampal abnormalities linked to doublecortin deficiency. Journal of Comparative Neurology. 2007. 500:239–254.

- Feki A., Teboul O., Dubois A., Bozon B., Faure A., Hantraye P., Dhenain M., Delatour B., Delzescaux T. Fully automated and adaptive detection of amyloid plaques in stained brain sections of Alzheimer transgenic mice. Medical Image Computing and Computer-Assisted Intervention. 2007;10(Pt 2):960-968.

- Teboul O., Feki A., Dubois A., Bozon B., Faure A., Hantraye P., Dhenain M., Delatour B., Delzescaux T. A standardized Method to Automatically Segment Amyloid Plaques in Congo Red Stained Sections from Alzheimer Transgenic Mice. Conf Proc IEEE Eng Med Biol Soc. 2007;1:5593-5596.

2006

- Dhenain, M., Delatour, B., Walczak, C., Volk, A., 2006. Passive staining: A novel ex vivo MRI protocol to detect amyloid deposits in mouse models of Alzheimer's disease. Magn. Reson. Med. 55, 687-693.

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